2014-02-17 03:32:01 - Atacand (Chronic Heart Failure) - Forecast and Market Analysis to 2022 - a new market research report on companiesandmarkets.com
AstraZeneca´s Atacand (candesartan) blocks the binding of angiotensin II to its receptor, inhibiting the effects of angiotensin, which include vasoconstriction, synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. It was launched for the treatment of hypertension in 1998 in the US, Europe, and Japan. In Japan, it is marketed by Takeda under the brand name Blopress. In 2004, 2005, and 2008, Atacand was approved for the treatment of CHF in Europe, the US, and Japan, respectively.
The chronic heart failure (CHF) market is a mature market that has been slowly overtaken by generic drugs, and more branded products are expected to lose market exclusivity during the next few years. We predict that the major global barriers that
will play a crucial role in narrowing the global growth of the CHF market over the forecast period include the sparsely populated CHF pipeline and an increasing number of generic competitors in a market that is already heavily laden with generic drugs.
However, the market entry of entry of Novartis´ LCZ-696, the first novel, branded CHF drug to enter the market in five years, will noticeably enhance the overall market size during the forecast period. LCZ-696 is currently being evaluated in a trial for patients with heart failure with reduced ejection fraction (HF-REF), but if clinical trial data continue to demonstrate the drug´s efficacy in patients with heart failure with preserved ejection fraction (HF-PEF), and it gains approval for use in this population, it will be the first drug to show efficacy in this largely underserved patient population. In addition, increased use of MRAs over the forecast period in all seven major markets (7MM) will contribute to the increase in the global CHF market size.
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