2014-02-17 03:31:01 - Diovan (Chronic Heart Failure) - Forecast and Market Analysis to 2022 - a new market research report on companiesandmarkets.com
Novartis´s Diovan was the first ARB agent that was indicated for hypertension and was subsequently approved for the treatment of patients with CHF, or patients with LVD who are stable following MI. Diovan was approved for hypertension in 1996 in the US and EU, and in 2000 in Japan. In 2002 and 2005, it gained regulatory approval for the treatment of CHF in the US and EU, respectively, and subsequently gained approval for CHF in Japan.
The chronic heart failure (CHF) market is a mature market that has been slowly overtaken by generic drugs, and more branded products are expected to lose market exclusivity during the next few years. We predict that the major global barriers that will play a crucial
role in narrowing the global growth of the CHF market over the forecast period include the sparsely populated CHF pipeline and an increasing number of generic competitors in a market that is already heavily laden with generic drugs.
However, the market entry of entry of Novartis´ LCZ-696, the first novel, branded CHF drug to enter the market in five years, will noticeably enhance the overall market size during the forecast period. LCZ-696 is currently being evaluated in a trial for patients with heart failure with reduced ejection fraction (HF-REF), but if clinical trial data continue to demonstrate the drug´s efficacy in patients with heart failure with preserved ejection fraction (HF-PEF), and it gains approval for use in this population, it will be the first drug to show efficacy in this largely underserved patient population. In addition, increased use of MRAs over the forecast period in all seven major markets (7MM) will contribute to the increase in the global CHF market size.
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