2014-04-03 00:27:01 - Bleeding Disorders: World Pharmaceutical Industry and Market 2014-2024 - a new market research report on companiesandmarkets.com
The global drugs market for preventing haemorrhages will generate $13.5bn in 2017. It is anticipated that the large medical companies and biopharma specialists will perform strongly over the next few years within the global bleeding disorders market.Between 2012 and 2018, revenue generated by sales of Helixate will increase at a CAGR of 0.16%. Between 2018 and 2024, revenue will decrease at a CAGR of -1.5%. In 2024, sales of the drug will generate $463m, accounting for 2.67% of the total market.Nplate represents the leading product for thrombocytopenia in 2012. Nplate is marketed by Amgen. It was approved by the FDA in August 2008 and by the EMA in February 2009 for the treatment of thrombocytopenia in adults with idiopathic thrombocytopenic
purpura, an autoimmune disease. It is a fusion protein analogue of thrombopoietin, a naturally occurring hormone which regulates platelet count. Nplate works by raising and sustaining the blood platelet count using the same mechanism of action as this hormone. Upon its launch, it represented a novel therapeutic approach to thrombocytopenia in this patient population.In 2012, sales of Nplate generated $368m. The product has seen strong annual growth in recent years. Driving this strong revenue generation is the chronic nature of the disease, which requires long term treatment, generating repeat sales. Additionally, Amgen is licensed to market Nplate in the US, all of Europe, Canada, Australia, New Zealand, Mexico, all Central and South American countries and certain countries in Africa, Asia and the Middle East meaning the drug is available to a large patient population. After approval, Nplate was subject to restricted distribution as a result of safety concerns arising from the limited experience with the drug. However, these Risk Evaluation and Modification Strategies (REMS) were modified in December 2011; prescribers, healthcare institutions, pharmacies and patients no longer have to enroll in REMS programmes in order to prescribe, dispense or take these drugs. This modification has resulted in an expanding market for Nplate.Amgen is conducting clinical trials with Nplate in the treatment of thrombocytopenia caused by hepatitis C, multiple myeloma and other cancers (chemotherapy-induced). Indication expansions will also result in an expanding market for Nplate. As a result of these factors, revenue generated by Nplate will see strong growth until 2016. Between 2012 and 2018, revenue generated by Nplate will expand at a CAGR of 7.65%. However, Nplate competes directly with GlaxoSmithKline´s Promacta and from 2016 onwards, the annual rate of growth in revenue will begin to decline as a result of market saturation.Revenue generated by Nplate will peak in 2020 at $590m, accounting for 3.76% of the total bleeding disorders market. From 2021 onwards competition in the market will result in negative annual growth. Between 2018 and 2024, revenue will decrease at a CAGR of -1.36%. In 2024, sales of Nplate will generate $527m, accounting for 3.05% of the total market.
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