2014-02-17 03:34:04 - LCZ-696 (Chronic Heart Failure) - Forecast and Market Analysis to 2022 - a new market research report on companiesandmarkets.com
Novartis is developing an orally-administered, dual-acting ARNi, LCZ-696, as a first-in-class combination drug. LCZ-696 consists of a 1:1 mixture of the ARB valsartan and the novel neprilysin inhibitor AHU-377. Valsartan, marketed as Diovan for the treatment of hypertension and CHF, is a selective angiotensin II type 1 (AT1) inhibitor that causes vasodilation of the blood vessels and blood pressure reduction. AHU-377 is a pro-drug that is activated by de-ethylation via esterases to form the LBQ657 metabolite. LBQ657 inhibits the enzyme neprilysin, which results in decreased circulation levels of atrial natriuretic (ANP) and NT-proBNP, a biomarker for left ventricular wall stress (Solomon et al., 2012). By combining these two molecules, LCZ-696 may provide additional cardio-renal protection over the currently marketed drugs.
chronic heart failure (CHF) market is a mature market that has been slowly overtaken by generic drugs, and more branded products are expected to lose market exclusivity during the next few years. We predict that the major global barriers that will play a crucial role in narrowing the global growth of the CHF market over the forecast period include the sparsely populated CHF pipeline and an increasing number of generic competitors in a market that is already heavily laden with generic drugs.
However, the market entry of entry of Novartis´ LCZ-696, the first novel, branded CHF drug to enter the market in five years, will noticeably enhance the overall market size during the forecast period. LCZ-696 is currently being evaluated in a trial for patients with heart failure with reduced ejection fraction (HF-REF), but if clinical trial data continue to demonstrate the drug´s efficacy in patients with heart failure with preserved ejection fraction (HF-PEF), and it gains approval for use in this population, it will be the first drug to show efficacy in this largely underserved patient population. In addition, increased use of MRAs over the forecast period in all seven major markets (7MM) will contribute to the increase in the global CHF market size.
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