2014-02-17 03:33:02 - Nebilet (Chronic Heart Failure) - Forecast and Market Analysis to 2022 - a new market research report on companiesandmarkets.com
Nebivolol, which was originally developed by Janssen and is marketed for CHF by Menarini as Nebilet and by Forest Laboratories as Nebilet, is a beta blocker with beta-1 selective properties when used at lower concentrations. Janssen received initial EMA approval for the drug´s use in hypertension in 1996; in 2005, Menarini (Janssen´s partner) received EMA approval for the additional indication of CHF.
The chronic heart failure (CHF) market is a mature market that has been slowly overtaken by generic drugs, and more branded products are expected to lose market exclusivity during the next few years. We predict that the major global barriers that will play a crucial role in narrowing the global growth of the CHF market over the forecast period
include the sparsely populated CHF pipeline and an increasing number of generic competitors in a market that is already heavily laden with generic drugs.
However, the market entry of entry of Novartis´ LCZ-696, the first novel, branded CHF drug to enter the market in five years, will noticeably enhance the overall market size during the forecast period. LCZ-696 is currently being evaluated in a trial for patients with heart failure with reduced ejection fraction (HF-REF), but if clinical trial data continue to demonstrate the drug´s efficacy in patients with heart failure with preserved ejection fraction (HF-PEF), and it gains approval for use in this population, it will be the first drug to show efficacy in this largely underserved patient population. In addition, increased use of MRAs over the forecast period in all seven major markets (7MM) will contribute to the increase in the global CHF market size.
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