PHARMACYCLICS - Ibrutinib - Promising to Deliver More - a new market research report on companiesandmarkets.com
PR-Inside.com: 2014-03-14 09:10:03
Our risk-reward analysis suggests that there is meaningful upside on positive PhIII data and approval of Ibrutinib (PCI-32765, PhIII, BTK inhibitor, partnered with JNJ, PhIII, CLL/SLL/PLL, MCL; PhII, DLBCL, MM, FL) in next two years.
Ibrutinib, a winner in the making - oral, once-daily dosing, high degree of B-cell specificity, has demonstrated remarkable efficacy and safety profile:
i) Tumor reduction (response) in heavily pretreated pts,
ii) Responses in pts previously treated with chemotherapy and with aggressive disease,
iii) Durable responses - many pts still on drug after prolonged period of time
iv) Patient tolerability including lack of bone marrow damage.
Ibrutinib is a best-in-class among leukemia drugs, showed durable efficacy in Tx-naÃ¯ve (TN) and refractory (R/R) CLL and MCL pts as a monotherpay and in combination studies which suggests a mega buster sales potential.
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