2013-03-13 17:47:29 - Recently published research from GlobalData, "Trobalt/Potiga (Epilepsy) - Forecast and Market Analysis to 2022", is now available at Fast Market Research

GlobalData has released its new PharmaPoint Drug Evaluation report, "Trobalt/Potiga (Epilepsy) - Forecast and Market Analysis to 2022". Epilepsy is a brain disorder characterized by spontaneously occurring and recurrent seizures. The market is heavily driven by the sales of antiepileptic drugs (AEDs) targeted at seizure reduction. The AED market is currently dominated by UCB's Keppra and GlaxoSmithKline's Lamictal. Although both drugs have experienced significant generic erosion, they form the mainstay of epilepsy treatment in the nine markets and will continue to have significant market share during the forecast period. Other key drugs include older generation AEDs such as Pfizer's Dilantin, Abbott's Depakote, and Novartis' Tegretol and Trileptal which still have significant usage due to their longevity in the market. However,

the AED dominance landscape will continue to shift towards newer generation drugs particularly following the recent market entry of GlaxoSmithKline's Trobalt/Potiga and Eisai's Fycompa which both offer first-in-class mechanisms of action.


Full Report Details at
- www.fastmr.com/prod/553316_trobaltpotiga_epilepsy_forecast_and_m ..


Trobalt/Potiga (retigabine/ezogabine) is a first-in-class AED that was originally developed by Valeant Pharmaceuticals International and is co-marketed globally with GSK. Although it was originaly registered under the molecular name retigabine, in 2010 it was assigned the name ezogabine in the US by the United States Adopted Name (USAN) council. Therefore, the drug has two generic names - ezogabine in the US and retigabine in the rest of the world. It was approved in 2011 in the EU, where it is marketed under the trade name Trobalt (retigabine), and also in the US, where it is marketed under the trade name Potiga (ezogabine). Although Trobalt officially launched in Europe in May 2011, the US launch has been delayed due to safety concerns regarding some adverse effects and its narcotic potential, which warranted further studies at the request of the FDA. Retigabine/ezogabine has a unique MOA compared with other AEDs on the market and works by targeting and opening a subset of potassium channels. It is believed that by facilitating the opening of specific neuronal potassium channels, retigabine increases the inhibitory effect of the potassium current and reduces the excitability of neuronal cells.

Scope

* Overview of Epilepsy, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
* Detailed information on Trobalt/Potiga including product description, safety and efficacy profiles as well as a SWOT analysis.
* Sales forecast for Trobalt/Potiga for the top six countries from 2012 to 2022.
* Sales information covered for the US, France, Germany, Italy, Spain and the UK

Reasons to buy

* Understand and capitalize by identifying products that are most likely to ensure a robust return
* Stay ahead of the competition by understanding the changing competitive landscape for Epilepsy
* Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
* Make more informed business decisions from insightful and in-depth analysis of Trobalt/Potiga performance
* Obtain sales forecast for Trobalt/Potiga from 2012-2022 in top six countries (the US, France, Germany, Italy, Spain and the UK)

Report Table of Contents:

1 Table of Contents
1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2 Introduction
2.1 Catalyst
2.2 Related Reports
3 Disease Overview
3.1 Classification of Seizures
3.2 Etiology and Pathophysiology
3.2.1 Etiology
3.2.2 Pathophysiology
3.2.3 Prognosis
3.2.4 Quality of Life
4 Disease Management
4.1 Diagnosis
4.2 Treatment Guidelines
4.3 Clinical Practice
5 Competitive Assessment
5.1 Overview
5.2 Strategic Competitor Assessment
6 Trobalt/Potiga (retigabine/ezogabine)
6.1 Overview
6.2 Therapeutic Role
6.3 Efficacy
6.4 Safety
6.5 SWOT Analysis
6.6 Forecast
7 Appendix
7.1 Bibliography
7.2 Abbreviations
7.3 Methodology
7.4 Forecasting Methodology
7.4.1 Prevalent Epilepsy Patients
7.4.2 Percent Drug-Treated Patients
7.4.3 General Pricing Assumptions
7.4.4 Individual Drug Assumptions
7.4.5 Generic Erosion
7.5 Physicians and Specialists Included in this Study
7.6 Primary Research - Prescriber Survey
7.7 About the Authors
7.7.1 Authors
7.7.2 Global Head of Healthcare
7.8 About GlobalData
7.9 Contact Us
7.10 Disclaimer

List of Tables

1.1 List of Tables
Table 1: Epilepsy Syndromes by Age at Onset (2009 ILAE Classification)
Table 2: Classification of Seizures
Table 3: Etiology of Epilepsy According to Age
Table 4: Etiology of Partial Seizures
Table 5: Etiology of Generalized Seizures
Table 6: Some of the Genes Involved in Epilepsy
Table 7: Summary of Diagnostic Tools for Epilepsy
Table 8: Treatment Guidelines for Epilepsy
Table 9: AED Options by Seizure Type
Table 10: Top Three AEDs Prescribed for Epilepsy by Market
Table 11: Types of Epilepsy Surgery
Table 12: Leading Treatments for Epilepsy, 2012
Table 13: Product Profile - Trobalt/Potiga
Table 14: Trobalt/Potiga SWOT Analysis, 2012
Table 15: Global Sales Forecasts ($m) for Trobalt/Potiga (retigabine/ezogabine), 2012-2022
Table 16: Physicians Surveyed, By Country

List of Figures

1.2 List of Figures
Figure 1: Summary of the Pathophysiology of Seizures by Net Increased Neuronal Excitation
Figure 2: Mechanisms of Action of AEDs at the Synapse
Figure 3: AED Selection Based on Comorbidity

About GlobalData

GlobalData is a leading provider of global business intelligence including market, competitor, product and customer information. It provides in-depth research, analysis, data and forecasts through a range of interactive online databases, reports and management briefings. GlobalData has a large team of experienced research and analysis, consulting, and marketing experts. It has a global presence, including key offices in the US, Europe and Asia. The group has over 50 years of experience of delivering market intelligence data and analysis and a highly experienced senior management team. View more research from GlobalData at www.fastmr.com/catalog/publishers.aspx?pubid=1015

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